AlternativeMaxolon
Metoclopramide
D2 antagonist / prokinetic
Antiemetic — limit to 5 days (EPSE risk).
OralIMIV
First-line for
- Hyperemesis (step 3)
- Post-op nausea
Mechanism
Central D2 block at CTZ + peripheral prokinetic.
Metoclo limit
- ≤5 days, max 30 mg/day
- EPSE — young women at risk
Dosing
- Dose
- 10 mg PO/IM/IV TDS ×5 days max
Contraindications
- AbsoluteGI obstruction/perforation, phaeochromocytoma
- CautionParkinson's, epilepsy
Side effects
- Acute dystonia / oculogyric crisis
- Tardive dyskinesia (prolonged)
- Hyperprolactinaemia
Fetal & maternal notes
- • Compatible — no teratogenic signal.
Key interactions
Antipsychotics
Avoid↑ EPSE
Levodopa
CautionAntagonism
Clinical pearls
- 💡 Procyclidine reverses acute dystonia.
- 💡 Domperidone alternative (less EPSE).
Content last reviewed: REPLACE_ME (e.g. 2026-07)
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