CautionDiflucan
Fluconazole
Triazole antifungal
Avoid oral in pregnancy — use topical imidazoles.
OralIV
First-line for
- Recurrent vulvovaginal candidiasis (non-pregnant)
Mechanism
Inhibits fungal CYP450 lanosterol 14α-demethylase → ↓ ergosterol.
Fluco pregnancy rule
- Oral: avoid (miscarriage / tetralogy at high dose)
- Topical clotrimazole = safe
Dosing
- Candida
- 150 mg PO single dose (non-pregnant)
Contraindications
- AbsolutePregnancy (oral); QT-prolonging drugs
Side effects
- Nausea, headache, ↑ LFTs
- QT prolongation
Fetal & maternal notes
- • High-dose teratogen (craniofacial); even single 150 mg ↑ miscarriage.
Key interactions
Warfarin
Avoid↑ INR
Statins
AvoidMyopathy
Sulfonylureas
CautionHypoglycaemia
Clinical pearls
- 💡 Pregnancy thrush → clotrimazole 500 mg PV stat ± cream 7 d.
- 💡 Test for diabetes if recurrent.
Content last reviewed: REPLACE_ME (e.g. 2026-07)
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