Erythromycin

• PPROM (preterm pre-labour ROM)
• Penicillin allergy + GBS / syphilis
• Chlamydia in pregnancy

Binds 50S ribosomal subunit → blocks protein synthesis (bacteriostatic).

• P — PPROM 250 mg QDS × 10 days
• P — Penicillin-allergic GBS
• C — Chlamydia (azithro preferred)

PPROM

250 mg PO QDS × 10 days or until delivery

Chlamydia

500 mg QDS × 7 days

• AbsoluteHepatic dysfunction
• CautionLong QT / class IA / III antiarrhythmics

• GI upset (very common)
• Cholestatic jaundice (estolate avoided)
• QT prolongation
• Pyloric stenosis in neonate

• • Avoid in T1 (pyloric stenosis association — small).
• • Safe in breastfeeding (preferred macrolide).

• Statins (simva)

  Avoid

  Rhabdomyolysis

• Warfarin

  Avoid

  ↑ INR

• QT-prolonging

  Avoid

  Torsades

• 💡 Avoid co-amoxiclav in PPROM (ORACLE → NEC).
• 💡 Switch to oral after 48 h IV if responding.